NCT01493362已完成不适用
Imaging the Dopamine Systems in Bulimia Nervosa
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- D2 receptor density
研究概览
简要总结
This study will use positron emission tomography imaging to investigate the dopamine systems in people with bulimia nervosa.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Participants with BN:
- •Meets DSM-IV criteria for BN
- •Sufficiently medically and psychiatrically stable to participate in research
- •Health Control Participants:
- •No current or past psychiatric illness
- •Between 80% and 120% of ideal body weight
排除标准
- •All participants:
- •Current use of psychotropic medication such as anti psychotics or antidepressants
- •Pregnant or breastfeeding
- •history of substance abuse
- •Significant medical illness
- •High blood pressure (resting systolic blood pressure greater than 150mmHg and diastolic blood pressure greater that 90 mmHg)
- •Current or lifetime history of schizophrenia, bipolar disorder, or other psychotic disorder as defined by DSM-IV
- •Metal implants or paramagnetic objects contained within the body that may interfere with the MRI scan, as determined in consultation with a neuroradiologist and according to specified reference book guidelines
- •Exposed to radiation in the workplace or has had a nuclear medicine procedure during the 1 year before study entry
- •Previous adverse reaction to psycho stimulants
结局指标
主要结局
D2 receptor density
时间窗: Measured at baseline
DA release in the striatum
时间窗: Measures after Mythlyphenidate challenge
次要结局
未报告次要终点
研究者
研究点 (1)
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