Clinical Efficacy of Novel Biogenically Fabricated Titania Nanoparticles Enriched Mouth Wash in Treating the Tooth Dentine Hypersensitivity: a Randamized Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 130
- 试验地点
- 1
- 主要终点
- Post mouth wash utilization Dentine Hypersensitivity
研究概览
简要总结
Randomized Clinical trial to compare the reduction in dentin hypersensitivity after incorporating biogenically fabricated titania nanoparticles enriched Mouth Wash and Conventional Mouth Wash.Participants ranging between 20-50 years were allocated in two groups. Group A will use Conventional Mouth Wash without Nanoparticles. Group B will use titania nanoparticles enriched Mouth Wash. Both will use them for three months and then their VAS scoring will be checked.
详细描述
In this study Novel biogenically fabricated titania nanoparticle reinforced Mouth Wash will be evaluated for dentine sensitivity . Participants following Inclusion criteria will be allocated in this study by Consecutive random sampling technique. Participants will be divided into two groups i.e Group-A and Group-B with dentin sensitivity of 30-80. Group A will be given Conventional Mouth Wash for three months and Group-B will be given titania nanoparticles enriched Mouth Wash for three months for the sensitivity. Sensitivity will be assessed using Visual analog scale (VAS) mean score after 1 month and then three months.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
盲法说明
This is a triple-blinded study in which the participant, care provider and outcome assessor will be masked
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants ranging between 20-50 years, good general health but developed dentine sensitivity associated with tooth surface wear and loss during the past 6 months.
- •There was no history of allergy.
- •Participants did not use any mouth wash , dentifrice or medication in the last 3 months.
- •The involved teeth were viable, non-shaky, devoid of any decay, cracks and fillings.
- •There was an essential positive response to the provoking Air stimuli.
- •These teeth should display the visible signs of tooth loss and wear such as : attrition, abrasion, erosion and abfraction.
排除标准
- •Participants that might have developed allergy or used medications during the last 2 weeks or more.
- •The teeth having cracks, decay and fillings were also excluded. Patients who have undergone any periodontal surgery or gross periodontal issues.
- •Participants who used any desensitisizing toothpastes/mouthwashes and tooth bleaching agents within 2 months of the trial were also excluded positively.
研究组 & 干预措施
Group-A: Conventional Mouth wash .
Group A will receive conventional mouthwash for treatment of dentin hypersensitivity
干预措施: Group- A Conventional Sensed Mouth Wash (Procedure)
Group-B: Novel Titania nanoparticles Mouth wash
Group B will receive novel Titania nano particles reinforced mouthwash for treatment of dentin hypersensitivity
干预措施: Group-B Novel Titania nanoparticles enriched Mouth Wash (Procedure)
结局指标
主要结局
Post mouth wash utilization Dentine Hypersensitivity
时间窗: 3 months
Evaluation of dentine hypersensitivity with Conventional Mouth Wash without titania nanoparticles and Novel Nps Mouth Wash with titania nanoparticles on human tooth dentin. Visual analog scale with scoring from 0 to 100 where Score 100 means worst outcomes.
次要结局
未报告次要终点
研究者
Afsheen Mansoor
Principal Investigator
Pakistan Institute of Medical Sciences