Markers of metabolic and oxidative stress in children with Down syndrome
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 86
- 试验地点
- 1
- 主要终点
- Means levels of Leptin and Adiponectin in children with DOWN syndrome
研究概览
简要总结
This study is a observational case control study to assess the metabolic and oxidative stress in children with Down Syndrome in comparison with age and gender matched healthy control population by estimating the mean levels of Leptin , Adiponectin and Superoxide Dismutase levels .Also the level of hepatic steatosis as measured by shear wave elastography . The study will be conducted in OPD’s and IPD’s of Department of Pediatrics in Maulana Azad Medical College and Associated Lok Nayak Hospital , New Delhi.
The objective of the study is to compare levels of Leptin , Adiponectin , SOD in children with Down syndrome with their healthy control siblings and to assess liver steatosis by shear wave elastography on ultrasonography . The hypothesis of our study is that children with Down Syndrome are at risk of high levels of oxidative stress which is linked to atheroscelerosis development , neurodegeneration , cell aging and cancer .
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 6.00 Month(s) 至 12.00 Year(s)（—）
- 性别
- All
入选标准
- •Children diagnosed with Down syndrome in this age group Control.
- •Children with no medical illness.
- •age and gender matched.
排除标准
- •Children with mosaic trisomy on karyotype. Control.
- •Childen with obesity and pre existing diabetes mellitus.
结局指标
主要结局
Means levels of Leptin and Adiponectin in children with DOWN syndrome
时间窗: Means levels of Leptin and Adiponectin in children with DOWN syndrome at first visit or day 1 | Mean levels of Superoxide dismutase in children with Down syndrome on first visit Association between the levels of these markers including lipid profile with BMI and hepatic steatosis as estimated with shear wave elastogaphy on first visit .
Mean levels of Superoxide dismutase in children with Down syndrome.
时间窗: Means levels of Leptin and Adiponectin in children with DOWN syndrome at first visit or day 1 | Mean levels of Superoxide dismutase in children with Down syndrome on first visit Association between the levels of these markers including lipid profile with BMI and hepatic steatosis as estimated with shear wave elastogaphy on first visit .
Association between the levels of these markers including lipid profile with BMI and hepatic steatosis as estimated with shear wave elastogaphy.
时间窗: Means levels of Leptin and Adiponectin in children with DOWN syndrome at first visit or day 1 | Mean levels of Superoxide dismutase in children with Down syndrome on first visit Association between the levels of these markers including lipid profile with BMI and hepatic steatosis as estimated with shear wave elastogaphy on first visit .
次要结局
- Means levels of Leptin & Adiponectin in children with DOWN syndrome(Mean levels of Superoxide dismutase in children with Down syndrome.)
研究者
Dr Arshida Husain
Maulana Azad Medical College