Admixture Mapping of Ethnic and Racial Insulin Complex Outcomes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 360
- 试验地点
- 1
- 主要终点
- To test the role of European genetic admixture on measures of insulin action and response in a multiethnic group of prepubertal children.
研究概览
简要总结
The main objective of this study is to investigate the effect of genetic and environmental parameters on racial/ethnic differences in aspects of insulin secretion and action. The genetic component will be modeled by estimating the degree of European genetic admixture (ADM) obtained from approximately 50 ancestry informative markers (AIMs). The environmental components will be modeled by measuring energy intake (food intake), energy expenditure (physical activity) and socioeconomic status.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 7 Years 至 12 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •African American, European American, or Hispanic American, aged 7-12, healthy, weight is equal to or greater than 25 Kg
排除标准
- •Type 1 or 2 diabetes, polycystic ovary disease, disturbances in glucose or lipid metabolism disturbances
- •Use of medication known to affect body composition or physical activity, diagnosis of genetic disorders known to affect body composition or fat distribution
- •Use of tobacco, alcohol consumption in excess of 400 g per week
- •Menstruated for more than a year prior to the recruitment; OR
- •A medical history that counter-indicates inclusion of the study
结局指标
主要结局
To test the role of European genetic admixture on measures of insulin action and response in a multiethnic group of prepubertal children.
时间窗: 5 years
To investigate whether the impact of energy intake, energy expenditure and socioeconomic status on proxy measures of insulin sensitivity and/or action differ as a function of European ADM in prepubertal children
时间窗: 5 years
To test phenotype-genotype associations between each one of the AIMs and measures of FI, SI and AIRg after adjusting for body composition in a sample of AA, HA and EA prepubertal children.
时间窗: 5 years
次要结局
未报告次要终点