Mood Effects of Serotonin Agonists Extended
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 56
- 试验地点
- 1
- 主要终点
- DASS-21
研究概览
简要总结
In this study we are examining the effects of repeated very low doses of serotonin agonists on mood individuals with negative mood.
详细描述
Here, we are examining the effects of four repeated low doses of lysergic acid diethylamide (LSD), compared to placebo, administered to healthy adults at 3-4 day intervals, on mood, cognitive performance and responses to emotional tasks
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •English fluency
- •High school level education
- •BMI between 19 and 30
排除标准
- •Diagnosed medical condition
- •women who are nursing, pregnant, or plan to become pregnant within 3 months
- •History of psychotic disorder or family history of psychotic disorder
研究组 & 干预措施
Placebo
Placebo
干预措施: Placebo (Drug)
Serotonin agonist 13ug
13ug of serotonin agonist
干预措施: Serotonin agonist - 13ug (Drug)
Serotonin agonist 26ug
26ug of serotonin agonist
干预措施: Serotonin agonist - 26ug (Drug)
结局指标
主要结局
DASS-21
时间窗: End of session 5, approximately 2 weeks from baseline
The primary outcome measure is the depression anxiety and stress scale (DASS) 21. This self-report measure contains 21 items and the range of scores for depression is 0-42, anxiety 0-42, and stress 0-42. Our primary outcome measure is total depression scale ratings during session 5, with lower scores indicating lower ratings of depression.
次要结局
未报告次要终点