The Role of Shear Stress in the Cerebrovascular Response to Acute Exercise
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- Cerebrovascular function
研究概览
简要总结
Cerebrovascular function and peripheral vascular function will be measured in healthy young adults, before and after acute bouts of aerobic exercise at various intensities.
详细描述
Acute bouts of aerobic exercise have been shown to enhance vascular reactivity of the peripheral circulation; however, the effects of a single exercise session on the cerebral circulation are unknown. This study will measure cerebrovascular function and peripheral vascular function before and after aerobic exercise at high and low intensities.
The research aims are:
- To determine if a single bout of aerobic exercise acutely enhances cerebrovascular function
- To determine the effect of aerobic exercise intensity and dose on cerebrovascular function in healthy adults.
- To determine if the acute exercise-induced changes in cerebrovascular function are associated with acute exercise-induced changes in peripheral vascular function in healthy adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Between 20-40 years old
- •BMI < 30 kg/m2
- •Recreationally active
- •Experience running on a treadmill
排除标准
- •Current smoker
- •History or evidence of: hepatic disease, renal disease, hematological disease, cardiovascular disease, stroke/neurovascular disease, diabetes
- •Taking blood pressure medication
- •History of depression or other mood related disorders
- •Part of a vulnerable population (e.g. pregnant women, prisoner, individuals lacking capacity to consent, etc.)
结局指标
主要结局
Cerebrovascular function
时间窗: Change in cerebrovascular function: measurements occur at baseline and 90 minutes post aerobic exercise to quantify magnitude of change.
Utilize ultrasound to measure a change in blood flow velocity in response to a breathing test
Peripheral vascular function
时间窗: Change in peripheral vascular function: measurements occur at baseline and 60 minutes post aerobic exercise to quantify magnitude of change.
Utilize ultrasound to measure a change in brachial artery diameter in response to reactive hyperemia
次要结局
未报告次要终点