Genetic Analysis of Head and Neck Squamous Cell Carcinoma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 74
- 主要终点
- Viral DNAs related to demographics, tumor characteristics, and patient prognosis
研究概览
简要总结
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This laboratory study is looking at DNA in tissue samples from patients with head and neck cancer.
详细描述
OBJECTIVES:
- Assess common genetic mutations in tumor and germline DNA samples from patients with head and neck squamous cell carcinoma (HNSCC).
- Search for viral DNAs and relate this information to demographics, tumor characteristics, and patient prognosis.
- Search for novel viral sequences and cancer-associated gene mutations in young nonsmoking HNSCC patients and in other distinct head and neck cancers.
- Determine tumor suppressor gene mutations in HNSCC patients and relate this information to gene expression data.
- Validate gene expression information using independent techniques such as real-time PCR on expressed sequences and immunohistochemistry.
OUTLINE: Genetic mutation analysis and gene expression studies are performed on tissue samples from patients with head and neck squamous cell carcinoma. Techniques used include real time-PCR and immunohistochemistry.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient with head and neck squamous cell carcinoma (HNSCC) enrolled in the Head and Neck Tissue Repository
- •Sufficient biological material collected to perform study tests
- •Historical material available from excess tissues at the Vanderbilt Pathology Department
排除标准
- •Not specified
- •PRIOR CONCURRENT THERAPY:
- •Not specified
结局指标
主要结局
Viral DNAs related to demographics, tumor characteristics, and patient prognosis
时间窗: Upon collection of final patient data
Assess common genetic mutations in tumor and germline DNA samples
时间窗: Upon collection of final patient data
Novel viral sequences and cancer-associated gene mutations in young nonsmoking patients with head and neck squamous cell carcinoma and in other distinct head and neck cancers
时间窗: Upon collection of final patient data
Tumor suppressor gene mutations related to gene expression data
时间窗: upon collection of final patient data
Validation of gene expression information using independent techniques such as real-time PCR on expressed sequences and immunohistochemistry
时间窗: upon collection of final patient data
次要结局
未报告次要终点
研究者
Barbara Murphy, MD
Professor of Medicine, Medical Oncologist
Vanderbilt-Ingram Cancer Center