Locoregional Recurrence After Neoadjuvant Versus Adjuvant Chemotherapy Based on Tumor Subtypes in Patients With Early-stage Breast Cancer: A Multi-institutional Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10,328
- 试验地点
- 1
- 主要终点
- Locoregional recurrence-free survival (LRR)
研究概览
简要总结
Neoadjuvant chemotherapy (NACT) for early-stage breast cancer is associated with an increased risk of locoregional recurrence (LRR). However, few studies have conducted subgroup analyses of patients with various molecular subtypes, which are one of the determinant factors for treatments. The aim of the study is to investigate whether the risk of LRR after NACT varies across tumor subtypes. The investigators retrospectively reviewed the medical records of female breast cancer patients who underwent breast-conserving surgery at three institutions between January 1, 2004, and Dec 31, 2018.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients who underwent breast-conserving surgery for invasive breast cancer between 2004 and 2018
排除标准
- •Total mastectomy
- •No pre- or postoperative chemotherapy
- •No radiation therapy
- •Bilateral breast cancer
- •Male breast cancer patients
- •Secondary breast cancer
- •Metachronous or synchronous cancers
结局指标
主要结局
Locoregional recurrence-free survival (LRR)
时间窗: Defined as the time interval between the date of initial administration of chemotherapy and date of pathological or radiological confirmation of LRR, assessed up to 120 months
Time interval between the date of initial administration of chemotherapy and date of pathological or radiological confirmation of locoregional recurrence
次要结局
- Distant metastasis-free survival(Defined as the time interval between the date of initial administration of chemotherapy and date of pathological or radiological confirmation of distant metastasis, assessed up to 120 months)
研究者
Wonshik Han
Clinical Professor
Seoul National University Hospital