Feasibility Trial of Magnetic-assisted Colonoscope Platform
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 10
- 主要终点
- Feasibility of magnetic-assisted colonoscope system
研究概览
简要总结
Colorectal cancer (CRC) screening program can reduce colon cancer-related mortality. Current CRC screening methods include stool occult blood and DNA testing, blood based tests and radiologic tests. Colonoscopy is considered the gold standard to detect colorectal neoplasms. Previous studies have estimated that cancer mortality to be 68% to 88% lower among persons who undergo screening colonoscopy than among those who do not. However, colonoscopy is an invasive examination, and 10% to 20% of patients fail to tolerate the procedure; therefore, greatly reduces the success rate of completion of colon examination.
External controllability of capsule endoscope by means of an applied magnetic field is a possible solution to the maneuvering problem. However, there is no effective system with straight forward clinical applicability till now. This is ascribable to a lack of reliable magnetic instrumentation suitable for such a purpose. We have reported that magnetic field navigator (MFN) can effectively control the locomotion of capsule endoscope. We have demonstrated the feasibility and safety of magnetic-assisted capsule endoscope for the examination of upper gastrointestinal tract. In this study, we develop a magnetic-assisted capsule colonoscope by combination of the integrated circuit complementary metal-oxide-semiconductor imaging sensor, light-emitting diode, and magnetic control technology. This magnetic-assisted capsule colonoscope operation system includes a MFN Platform, high-end hand-controlled joystick, combined circuit component, control interface and software. This magnetic-assisted capsule colonoscope operation system creates a friendly operating environment for the operators, and may establishe a novel screening system for the colon.
详细描述
- Preparation before examination: All subjects must take bowel cleansing drugs as instructed before magnetically controlled colonoscopy After starting to drink laxatives, subjects should continue their daily activities .
- Magnetically Controlled Colonoscopy procedure:
No anesthesia will be used during the magnetically controlled colonoscopy in this experiment.
The subjects lie down on the magnetic control colonoscopy platform. After the magnetically controlled colonoscopy enters the rectum from the subject's anus, the external magnetron is used to assist and guide the pre-colonoscopy after the magnetically controlled colonoscopy enters the rectum from the subject's anus, and the external magnetron is used to assist and guide the colonoscopy go ahead. During the inspection process, the physician monitors the operation of the magnetically controlled colonoscope throughout the process, and the physician can adjust the movement of the colonoscope when necessary.
Whole colorectal examination is defined as the colonoscope must be inserted into the ileocecal region, and the cecum must be photographed. 3. Pain assessment during examination:
During the colonoscopy, the researchers will conduct a questionnaire to the patients to assess the pain..
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Device Feasibility
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged 20-65 health volunteers without any contraindication
排除标准
- •Person allergy to polyethylene glycol.
- •Phenylkentouria
- •Congestive heart failure (NYHA grade 3)
- •Renal function impairment.
- •Difficulty in swallowing, GI perforation, GI bleeding, toxic enterocolitis, toxic colitis, megacolon, diverticulitis, peritonitis
- •Body weight less than 20kg
- •Wrist more than 120cm
- •Gastrointestinal tract obstruction
- •Pregnant woman.
- •Person with electrical medical implantation such as pacemaker, cochlear implant or other medical devices.
- •Person implanted with metal medical device such as metal implantation, metallic stent, metallic denture, metallic valve, metallic joint, metallic joint or plate.
- •Person with history of abdominal surgery.
- •Person with cancer.
- •Person with bleeding tendency
- •Person with asthma
- •History of cardiac infraction, pulmonary embolism, stroke in recent 6 months
- •Heart failure with NYHA grades 4
结局指标
主要结局
Feasibility of magnetic-assisted colonoscope system
时间窗: The end of colonoscopic examination
The completion rate of colonoscopic examination by using the magnetic-assisted colonoscope system
Safety of magnetic-assisted colonoscope system
时间窗: The end of colonoscopic examination
The complication rate of colonoscopic examination by using the magnetic-assisted
次要结局
未报告次要终点
研究者
Fat-Moon Suk
Attending physician
Taipei Medical University WanFang Hospital