Platelet Reactivity In Patients With Nuisance Bleeding On A Thienopyridine
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- platelet reactivity
研究概览
简要总结
The objective is to describe and quantify levels of platelet reactivity in three different cohorts of patients taking thienopyridine: patients who report nuisance bleeding, patients who report alarming bleeding, and patients who report no nuisance or alarming bleeding. The investigators hypothesize that patients with nuisance or alarming bleeding events on maintenance thienopyridine therapy will have lower levels of platelet reactivity than patients without nuisance or alarming bleeding on thienopyridine therapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients 18 years or older from both genders
- •Underwent PCI within the last year
- •Taking maintenance dose of clopidogrel 75 mg once a day or prasugrel 10 mg once a day for at least five days
排除标准
- •Known allergies to aspirin, clopidogrel, or prasugrel.
- •Use of a glycoprotein (GP)IIb/IIIa inhibitor within 8 hours of the blood draw.
- •Patient known to be pregnant or lactating
- •Patient with known history of anemia, thrombocytopenia, bleeding disorder, or currently active bleeding
- •On warfarin therapy at the time of blood draw
- •Known blood transfusion within the preceding 10 days of the blood draw
- •Patients treated with non-steroidal anti-inflammatory drugs (NSAIDS, not to include aspirin) within the previous 5 days
- •Any significant medical condition that, in the investigator's opinion, may interfere with the patient's optimal participation in the study.
结局指标
主要结局
platelet reactivity
时间窗: post percutaneous coronary intervention (PCI) while still on clopidogrel
Level of platelet reactivity as assessed with the Chrono-Log Lumi-Aggregometer, which measures levels of light transmittance after stimulation with ADP to estimate levels of platelet aggregation.
次要结局
- Platelet reactivity(post PCI while still on clopidogrel)