Stylistic Memory Enhancement
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 主要终点
- California Verbal Learning Test (CVLT-II- Total learning
研究概览
简要总结
Impairments in higher level cognitive processing, such as new learning and memory, are common in Multiple Sclerosis (MS) and negatively impact multiple aspects of everyday life, including occupational and social functioning. Despite this, few studies have attempted to remediate these cognitive deficits in order to improve everyday functioning. While not applied in traditional rehabilitation protocols as of yet, many techniques from cognitive psychology significantly improve learning and memory in healthy persons. These techniques include the generation effect (GE), the spacing effect (SE), and the testing effect (TE). These techniques have recently been incorporated into an 8-session treatment protocol, Stylistic Memory Enhancement (SME), designed to teach participants about each of the techniques, train them on how to apply the techniques in daily life and practice their application to daily life memory demanding situations. The protocol includes teaching participants how to restructure a memory demanding situation in order to make optimal use of self-generation, spaced learning and self-testing. The objective of the study is to test the efficacy of the SME in an MS population.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 59 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinically definite MS between the ages of 18 and
- •Participants must have impairment in new learning (determined by an in-person screen) with intact language comprehension.
排除标准
- •History of alcohol or drug abuse/dependence,
- •Major psychiatric disturbance (e.g. bipolar disorder, schizophrenia) and neurological history other than MS.
- •Corticosteroid use within the last month prior to the participation.
- •Less than 1 month post most recent exacerbation.
结局指标
主要结局
California Verbal Learning Test (CVLT-II- Total learning
时间窗: Baseline and post-intervention (5 weeks between testing sessions)
Measure of change in new learning
次要结局
- Memory Functioning Questionnaire(Baseline and post-intervention ( 5 weeks between testing sessions))
研究者
Nancy Chiaravalloti
Director Neuropsychology and Neuroscience Research
Kessler Foundation
