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临床试验/NCT03206034
NCT03206034已完成不适用

Stylistic Memory Enhancement

Kessler Foundation0 个研究点目标入组 20 人开始时间: 2013年3月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
20
主要终点
California Verbal Learning Test (CVLT-II- Total learning

研究概览

简要总结

Impairments in higher level cognitive processing, such as new learning and memory, are common in Multiple Sclerosis (MS) and negatively impact multiple aspects of everyday life, including occupational and social functioning. Despite this, few studies have attempted to remediate these cognitive deficits in order to improve everyday functioning. While not applied in traditional rehabilitation protocols as of yet, many techniques from cognitive psychology significantly improve learning and memory in healthy persons. These techniques include the generation effect (GE), the spacing effect (SE), and the testing effect (TE). These techniques have recently been incorporated into an 8-session treatment protocol, Stylistic Memory Enhancement (SME), designed to teach participants about each of the techniques, train them on how to apply the techniques in daily life and practice their application to daily life memory demanding situations. The protocol includes teaching participants how to restructure a memory demanding situation in order to make optimal use of self-generation, spaced learning and self-testing. The objective of the study is to test the efficacy of the SME in an MS population.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Triple (Participant, Investigator, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 59 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Clinically definite MS between the ages of 18 and
  • Participants must have impairment in new learning (determined by an in-person screen) with intact language comprehension.

排除标准

  • History of alcohol or drug abuse/dependence,
  • Major psychiatric disturbance (e.g. bipolar disorder, schizophrenia) and neurological history other than MS.
  • Corticosteroid use within the last month prior to the participation.
  • Less than 1 month post most recent exacerbation.

结局指标

主要结局

California Verbal Learning Test (CVLT-II- Total learning

时间窗: Baseline and post-intervention (5 weeks between testing sessions)

Measure of change in new learning

次要结局

  • Memory Functioning Questionnaire(Baseline and post-intervention ( 5 weeks between testing sessions))

研究者

发起方
Kessler Foundation
申办方类型
Other
责任方
Principal Investigator
主要研究者

Nancy Chiaravalloti

Director Neuropsychology and Neuroscience Research

Kessler Foundation

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