Clinical trial evaluating the clinical efficacy of dexamethasone sodium phosphate and dexamethasone palmitate for pain management before and after surgery for knee joint arthroplasty_ randomized, double-blind, clinical study

Korea University Ansan Hospital0 个研究点目标入组 114 人开始时间: 待定最近更新: 2024年4月29日

试验速览

暂无简介。

•Inclusion Criteria:
•Patients diagnosed with primary osteoarthritis of the hip joint who have received symptomatic treatment (medication, physical therapy) but have not achieved adequate pain control and are scheduled to undergo hip joint replacement surgery at the hospital, who understand the research content and agree to participate in the study.

•Exclusion Criteria:
•Age below 60 or above 80 years.
•Patients undergoing revision hip replacement surgery.
•Joint arthritis other than primary osteoarthritis (e.g., rheumatoid arthritis, psoriatic arthritis, gouty arthritis, lupus arthritis, post-traumatic arthritis, etc.).
•Hemoglobin level exceeding 8% before surgery.
•Surgery performed under spinal anesthesia rather than general anesthesia.
•Concurrent surgical procedures other than hip joint replacement during surgery.
•Use of steroids due to the patient's underlying condition before surgery (e.g., patients undergoing steroid inhaler therapy, patients receiving steroid replacement therapy due to adrenal insufficiency, etc.).
•Use of self-administered pain control devices after surgery.
•Administration of steroid injections within 3 months before surgery (intravenous, intra-articular, etc.).
•Use of steroids for purposes other than the study objectives during hospitalization after surgery (e.g., spinal or joint injections).
•Occurrence of postoperative medical emergencies requiring additional treatment (e.g., stroke, acute coronary syndrome, acute respiratory distress syndrome).
•Allergy to dexamethasone sodium phosphate or dexamethasone palmitate.
•Hypersensitivity or allergy to soybean oil.
•Patients with hypersensitivity to soybeans or peanuts.

发起方