Comparison of Anterior and Posterior Corneal Astigmatism in Patients With Keratoconus and Controls
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 主要终点
- Comparison between astigmatism in patients with keratoconus and normal people.
研究概览
简要总结
Keratoconus is a bilateral (but usually asymmetrical) non-inflammatory progressive thinning process of the cornea. It manifests as characteristic cone-like ectasia of the cornea associated with irregular stromal thinning, resulting in a cone-like bulge , which causing irregular astigmatism and vision impairment.
详细描述
Keratoconus is the most common form of corneal ectasia, with an incidence of 50-230 per 100,000 persons.Pentacam used diagnose & detect the progression in patients with keratoconus and also provide a detailed information about corneal tomography and topography.
In the last few years, it has been shown that in healthy individuals the posterior corneal surface has not only a different amount of astigmatism but also a different alignment of the steep meridian.
The aim of this research is to compare the amount and axis alignment of anterior and posterior corneal astigmatism in keratoconus with a healthy controlled group .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients diagnosed with keratoconus using the following criteria:
- •Specific diagnostic signs is asymmetric refractive errors with high progressive or irregular astigmatism, and elevated keratometry values, scissoring of the red reflex, Vogt striae, Fleischer rings, inferior or central steepening on topography with abnormal localized steepening .
排除标准
- •Unwillingness to participate in the study .
- •Corneal scarring.
- •Any ectatic conditions that were not explicitly keratoconus such as keratoglobus and pellucid marginal degeneration .
- •Previous ocular surgery.
研究组 & 干预措施
Patients with keratoconus
Pentacam will be used for comparison between astigmatism in patients with keratoconus and normal people at the same age and sex.
干预措施: Pentacam (Device)
Normal people at the same age and sex
Pentacam will be used for comparison between astigmatism in patients with keratoconus and normal people at the same age and sex.
干预措施: Pentacam (Device)
结局指标
主要结局
Comparison between astigmatism in patients with keratoconus and normal people.
时间窗: Two years
Pentacam will be used for comparison between astigmatism in patients with keratoconus and normal people at the same age and sex
次要结局
未报告次要终点
研究者
Doaa Mamdouh
Principal investigator
Assiut University