The Effect of Blueberry Consumption on Cognition and Body Composition in Elderly Who Are Experiencing Mild Cognitive Decline
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 123
- 试验地点
- 1
- 主要终点
- Change in cognitive test performance
研究概览
简要总结
Purpose: The purpose of this study is to examine the effect of blueberry consumption on cognitive decline and body composition in humans.
Hypothesis 1: Adults with mild cognitive decline who consume blueberries will experience an improvement in cognitive abilities as measured by a standardized battery of tests, relative to those who consume a placebo.
Hypothesis 2: Adults with mild cognitive decline who consume blueberries will evidence an increase in processing speed and an improvement in memory abilities as measured in an electrophysiological paradigm and compared to those who consume a placebo.
Hypothesis 3: Daily intake of 35 g freeze-dried blueberries will improve body composition (fat mass vs. lean mass).
Hypothesis 4: Daily intake of 35 g freeze-dried blueberries will decrease oxidative stress and inflammatory markers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 65 Years 至 79 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women age 65 and older
- •BMI between 18.5 and 34.5
- •Close individual to report memory decline
排除标准
- •History of central nervous system or psychiatric disorders
- •Dementia or Alzheimer's diagnosis
- •Smoking >20 cigarettes/day
- •Gastrointestinal/digestive disorders
- •Uncontrolled chronic disease
研究组 & 干预措施
Blueberry Group
37 grams of dehydrated blueberries daily for 6 months
干预措施: Freeze-dried blueberries (Dietary Supplement)
Placebo Group
37 grams of dextrose powder daily for 6 months
干预措施: Dextrose Placebo (Dietary Supplement)
Reference Group
No intervention
结局指标
主要结局
Change in cognitive test performance
时间窗: Baseline, 180 days
Measured by CANTAB
Change in brain activity (N200, P300) related to cognitive abilities as measured by event-related potentials (ERP)
时间窗: Baseline, 180 days
Recognition memory, speed of processing, and memory consolidation as measured by the electrophysiological technique known as event-related potentials (ERP)
次要结局
- Change in body mass distribution(Baseline, 180 days)
- Change in oxidative stress and inflammatory markers as measured in blood and urine(Baseline, 180 days)
研究者
Carol Cheatham, PhD
Assistant Professor of Psychology
University of North Carolina, Chapel Hill