Study MOTIF : mTOR Inhibitors: the Lesions Induced by Papillomavirus for Transplant Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Evolution of HPV related lesions in patient without switch
研究概览
简要总结
The injuries induced by Human Papillomavirus (HPV) (anogenital condyloma mainly) are more frequent among transplanted patients due to their immunosuppression. These injuries are benign but they have a negative impact on the patients' quality of life. The initial treatment is topical and then surgical. The injuries can relapse, especially among transplanted patients.
The modification of the immunosuppressant treatment with a switch to mTOR inhibitors (mammalian Target Of Rapamycin) has shown its efficacy in preventing the recurrence of squamous cell carcinomas or treating Kaposi's disease.
By analogy, this therapeutic strategy can be sometimes put forward to transplanted patients with HPV-induced injuries.
The principal objective of this study is to describe the evolution of HPV-induced lesions in solid organ transplant patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patient (Age ≥ 18 years)
- •Transplanted patient (any organ), having developed HPV-induced lesions after transplantation
- •Patient followed or having been followed at Edouard Herriot Hospital (HEH)
- •Patient having been informed and not having objected to participating in the study
排除标准
- •Transplanted patient without HPV-induced lesions
结局指标
主要结局
Evolution of HPV related lesions in patient without switch
时间窗: at inclusion
At one year of the first HPV related lesions care then remotely (by tacking the last medical encounter) for the patients without the switch.
Evolution of HPV related lesions in patient with switch
时间窗: at inclusion
At one year of the switch by an inhibitor of mTOR then remotely of the switch (by tacking the last medical encounter) for the patients concerned by the switch.
次要结局
未报告次要终点