Neural Mechanisms Mediating Appetitive Regulation and Smoking in Nicotine Addiction
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 4
- 主要终点
- Magnitude of change in fMRI brain response to images
研究概览
简要总结
The purpose of this study is to evaluate the effectiveness of two behavioral interventions on smoking behavior - Mindfulness-Oriented Recovery Enhancement (MORE) and Cognitive Behavioral Therapy (CBT). MORE is a behavioral therapy that integrates mindfulness training to modify reward processes. CBT is a therapy designed to help individuals understand how their thoughts and feelings influence their behaviors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18 and up
- •English fluency as demonstrated in providing informed consent and the ability to independently follow directions in completing assigned assessments and tasks
- •Functional vision (with corrective lenses as needed) to complete assigned assessments and tasks
- •Current nicotine dependent smoker with a minimum smoking history of 2 years
- •Interest in quitting smoking
排除标准
- •Use of psychotropic (e.g. antiepileptic) medications in the past month
- •Positive urine drug screen
- •Presence of an untreated medical illness
- •Current or past psychosis
- •History of major neurological illness or head injury resulting in loss of consciousness
- •And contraindication to MRI, including claustrophobia
- •Among females, positive urine pregnancy test
- •Inability or unwillingness of subject to give informed consent
结局指标
主要结局
Magnitude of change in fMRI brain response to images
时间窗: 7 weeks
Measure the effects of MORE on fMRI BOLD response to images (change from baseline to end of study) while participants undergo functional magnetic resonance imaging
Magnitude of change in fMRI brain connectivity
时间窗: 7 weeks
Measure the effects of MORE on resting-state functional connectivity (change from baseline to end of study) while participants undergo functional magnetic resonance imaging.
Cigarette Smoking
时间窗: 7 weeks
Biochemical smoking assessment (breath carbon monoxide) at each study visit.
次要结局
未报告次要终点
研究者
Brett Froeliger
Professor Psychiatry
University of Missouri-Columbia