The Relationship Between Motor Cortex Oxygenation and Motor Function Recovery in Stroke Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Cortical activation
研究概览
简要总结
Stroke is the most common cause of motor function impairment. However, the functional impairment is not totally irreversible. Several mechanisms may involved in both the cortical and motor function recovery after onset of stroke, and most of them are related to changes of cortical perfusion and metabolism.
Motor function recovery after stroke (especially middle cerebral artery territory lesion) frequently follow stereotypic pattern (brunnström stage).
This study is designed to investigate the relationship between motor cortex oxygenation/metabolism and motor function recovery after stroke. To seek if there is similar stereotypic pattern of motor cortex oxygenation/metabolism change during the recover stage after stroke.
详细描述
Participants receive evaluations (1/week for 3 months period) of
- motor function (Include: MMSE, brunnström stage, Fugl-Meyer Assessment of Physical Performance, Box and Block Test of Manual Dexterity, Functional Independence Measure)
- cortical perfusion detection during performing limb movements (using NIRS)
Then use path analysis to investigate the relationship between motor cortex oxygenation/metabolism and motor function recovery after stroke.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 45 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Ischemic stroke(unilateral, onset within 7 days, without previous stroke history)
- •Vital sign stable
- •Upper extremity motor function impairment(brunnström stage I~III)
排除标准
- •with pacemakers
- •Seizure history
- •Serious dysrhythmias
- •Poor cognition function(MMSE<13)
结局指标
主要结局
Cortical activation
时间窗: weekly changes within 3 months
Using Near-infrared spectroscopy to measure cortical activation changes weekly for 3 months
次要结局
- motor function(weekly changes within 3 months)
研究者
Zheng-Yu Hoe, MD., PhD.
Principal Investigator
Kaohsiung Veterans General Hospital.