NCT06215612尚未招募不适用
ctDNA and MR Imaging Parameters as Possible Biomarkers in Primary Radiochemotherapy of Head and Neck Squamous Cell Carcinomas
Franziska Eckert0 个研究点目标入组 50 人开始时间: 2024年2月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
- 主要终点
- percentage of patients with 50% decrease in ctDNA
研究概览
简要总结
Patients undergoing primary radiochhemotherapy for locally advanced head and neck squamous cell carcinomas are included in this study. In addition to standard of care treatment patients will undergo addiational blood draws and MR imaging studies. Circulating cell free tumor DNA will be analysed in the blood samples. BIological data, imaging data and clinical data (such as patient and tumor characteristics, oncologic outcome, side effects) will be analysed in a biomathematical modelling approach.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Squamous cell carcinoma head and neck
- •Planned primary platinum based radiochemotherapy
排除标准
- •Palliative therapy intent
- •Not MR eligible
结局指标
主要结局
percentage of patients with 50% decrease in ctDNA
时间窗: 7 weeks after start of radiotherapy
次要结局
- Completion of all planned MR imagings and blood tests(through study completion, an average of 7 weeks)
- Decrease of tumor volume(7 weeks after start of radiotherapy)
研究者
Franziska Eckert
Deputy Head of Department
Medical University of Vienna
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