The Effects of Pistacia Mutica on De Novo Dental Plaque Formation, Gingival Inflammation and Oral Microorganisms
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- The effects of pistacia Mutica extract (PM) on de novo plaque formation.
研究概览
简要总结
Dental plaque is a well known etiologic factor for gingivitis. Recently, herbal extracts are a matter of scientific interest to inhibit plaque accumulation on teeth. The purpose of this study was to evaluate the effects of pistacia Mutica (PM) mouth wash on de novo dental plaque plaque formation, gingival inflammation indices and oral microorganisms.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •had merely gingivitis (pocket depth≤3 mm, no attachment loss)
- •without any fixed or removable oral appliances
排除标准
- •Individuals who had a history of any relevant systemic diseases
- •Individuals who had a history of any drug usage
研究组 & 干预措施
pistacia Mutica
The subjects were asked to use a mouthwash containing pistacia Mutica extract twice a day for 4 days.
干预措施: pistacia Mutica extract (Drug)
placebo
The subjects were asked to use a mouthwash containing Placebo twice a day for 4 days.
干预措施: Placebo (Drug)
Chlorhexidine
The subjects were asked to use a mouthwash containing Chlorhexidine twice a day for 4 days.
干预措施: Chlorhexidine (Drug)
结局指标
主要结局
The effects of pistacia Mutica extract (PM) on de novo plaque formation.
时间窗: In a 4 days experimental periods followed by a 10 days wash-out periods.
次要结局
- staining effects of pistacia Mutica extract in comparison to placebo or Chlorhexidine(In a 4 days experimental periods followed by a 10 days wash-out periods)