Assessing implications for prognosis and management of non-infectious uveitis based on novel inflammatory serum biomarkers.

Uveitis causes serious complications; e.g., chronic eye inflammation, keratopathy, cataract, glaucoma, macular edema, retinal detachment, and result in permanent vision loss if not diagnosed and treated promptly.

To identify if C-reactive protein (CRP)/albumin ratio (CAR) and systemic immune-inflammation index (SII) in patients with non-infectious uveitis during an attack is a marker that can give information about the activity, severity and prognosis of the disease. No prospective study is done in the past. No Indian study in the past. Identification of patients with noninfectious uveitis requiring steroid-sparing immunomodulatory therapy (IMT) is currently lacking in objective molecular biomarkers. Early detection of this can help prevent recurrence and complications of disease.