Investigation of the Relationship Between Monocyte Distribution, Monocyte-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio With Acute Phase Reactants in Sepsis in the Intensive Care Unit
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- WBC,NLR,MLR,MD,LACTATE,CRP,PCT
研究概览
简要总结
The aim of this study is to investigate, in patients admitted to the intensive care unit either for reasons other than sepsis who subsequently develop sepsis or with a primary diagnosis of sepsis, whether monocyte distribution, monocyte-to-lymphocyte ratio, and neutrophil-to-lymphocyte ratio can be used in addition to conventional biomarkers, and to examine their relationships with these biomarkers.
详细描述
For Group I (control group) patients, WBC, NLR, MLR, and monocyte distribution(MD) parameters obtained from the complete blood count on the day of their anesthesia outpatient clinic visit were used in the study. For Group II and Group III patients, on the day of sepsis diagnosis, lactate, CRP, PCT, WBC, NLR, MLR, and monocyte distribution(MD) values were recorded. For Groups II and III, SOFA and APACHE-II scores were calculated within the first 24 hours and documented. The day of sepsis diagnosis was defined as T0, and subsequent measurements of lactate, CRP, PCT, WBC, NLR, MLR, and monocyte distribution(MD) were recorded every 48 hours until sepsis resolution, discharge, or death, as T1, T2, T3, and T4, respectively. The monocyte distribution parameter is a research parameter within the complete blood count and does not have a defined reference laboratory range. In our study, statistical analysis of monocyte distribution(MD), MLR and NLR values from the control group was performed to determine a cut-off value.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients monitored in the intensive care unit for at least 24 hours
- •Age over 18 years
- •Diagnosis of sepsis or septic shock
排除标准
- •Patients with hematological diseases
- •Patients who have undergone organ or bone marrow transplantation
- •Patients diagnosed with AIDS
- •Patients receiving immunosuppressive therapy for any reason
- •Patients with chronic renal failure
- •Patients with liver failure not related to sepsis
- •Patients admitted due to intoxication
- •Patients with intracranial pathologies (e.g., mass, hemorrhage) that may lead to morbidity due to volume loading
研究组 & 干预措施
Group-I: Control
Control group - patients over 18 years of age, classified as ASA I-II, with no infection, who applied to the anesthesia outpatient clinic and did not meet any exclusion criteria.
干预措施: Monocyte Distribution (Diagnostic Test)
Group-II
Group II: patients who were admitted to the intensive care unit for reasons other than sepsis and subsequently developed sepsis
干预措施: Monocyte Distribution (Diagnostic Test)
Group-III
Group III: patients admitted to the intensive care unit with a primary diagnosis of sepsis.
干预措施: Monocyte Distribution (Diagnostic Test)
结局指标
主要结局
WBC,NLR,MLR,MD,LACTATE,CRP,PCT
时间窗: 15 days
For Group I (control group) patients WBC, NLR, MLR and monocyte distribution(MD) parameters obtained from the complete blood count on the day of their anesthesia outpatient clinic visit were used in the study. For Group II and Group III patients, on the day of sepsis diagnosis, lactate, CRP, PCT, WBC, NLR, MLR and monocyte distribution(MD) values were recorded. The day of sepsis diagnosis was defined as T0 and subsequent measurements of lactate, CRP, PCT, WBC, NLR, MLR, and MD were recorded every 48 hours until sepsis resolution, dischargevor death as T1, T2, T3, and T4, respectively. The monocyte distribution parameter is a research parameter within the complete blood count and does not have a defined reference laboratory range. In our study, statistical analysis of MD, MLR and NLR values from the control group was performed to determine a cut-off value. \[WBC 10\^3/mm3, CRP mg/L, PCT ng/mL,Lactate mmol/L, NLR 2-90(min-max), MLR 0.24-1.3(min-max), MD 8.9-13(min-max)\]
次要结局
- SOFA and APACHE-II scores(Within the first 24 hours following the diagnosis of sepsis)
研究者
Oguz Gundogdu
Associate Professor
Cumhuriyet University