Can a Moderate Intensity Exercise Training Programme Improve Cardiac Function and Known Cardiovascular Risk Factors in Middle-aged Women?
试验速览
- 阶段
- 2 期
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Maximal oxygen uptake
研究概览
简要总结
The purpose of this study was to examine the effect of 6 months moderate intensity exercise training completed three times per week upon traditional and emerging cardiovascular disease risk factors in postmenopausal women both with and without type 2 diabetes. These risk factors include blood markers associated with increased risk such as cholesterol, insulin, glucose and markers of inflammation plus measures of body fat, heart and lung fitness, vascular stiffness and vascular function. The study hypothesised that moderate intensity exercise training would intervene in the exaggerated risk seen in women following the menopause, especially in those with type 2 diabetes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 45 Years 至 65 Years(Adult, Older Adult)
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Healthy and stable type II diabetic postmenopausal women (cessation of menstrual periods for 12 months and confirmed with LH/FSH samples) aged 45 - 65 years old for the cross sectional analysis and exercise training study.
排除标准
- •Identified abnormalities during baseline testing.
- •Vigorously active women.
- •Women who are pregnant.
- •Women with serious systemic or psychological disorders (e.g. COPD, asthma, clinical depression).
- •Women with known coronary artery disease.
- •Women with significant cardiovascular pathologies and associated medication.
- •Women with type 1 or insulin treated diabetes.
- •Women with diabetes with complications.
- •Women with unstable diabetes or hypertension.
- •Women with any cancer.
- •Women with musculoskeletal impairments or contraindications to exercise.
结局指标
主要结局
Maximal oxygen uptake
时间窗: 6 months
次要结局
- lipoprotein profile(6 months)
- Flow mediated dilation(6 months)
- Cardiac power output(6 months)
- Arterial stiffness(6 months)
- Inflammatory markers(6 months)
- Body composition(6 months)
