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临床试验/NCT01219725
NCT01219725Unknown2 期

Can a Moderate Intensity Exercise Training Programme Improve Cardiac Function and Known Cardiovascular Risk Factors in Middle-aged Women?

University of Leeds2 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2005年7月最近更新:
适应症

试验速览

阶段
2 期
入组人数
100
试验地点
2
主要终点
Maximal oxygen uptake

研究概览

简要总结

The purpose of this study was to examine the effect of 6 months moderate intensity exercise training completed three times per week upon traditional and emerging cardiovascular disease risk factors in postmenopausal women both with and without type 2 diabetes. These risk factors include blood markers associated with increased risk such as cholesterol, insulin, glucose and markers of inflammation plus measures of body fat, heart and lung fitness, vascular stiffness and vascular function. The study hypothesised that moderate intensity exercise training would intervene in the exaggerated risk seen in women following the menopause, especially in those with type 2 diabetes.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
Single (Outcomes Assessor)

入排标准

年龄范围
45 Years 至 65 Years(Adult, Older Adult)
性别
Female
接受健康志愿者

入选标准

  • Healthy and stable type II diabetic postmenopausal women (cessation of menstrual periods for 12 months and confirmed with LH/FSH samples) aged 45 - 65 years old for the cross sectional analysis and exercise training study.

排除标准

  • Identified abnormalities during baseline testing.
  • Vigorously active women.
  • Women who are pregnant.
  • Women with serious systemic or psychological disorders (e.g. COPD, asthma, clinical depression).
  • Women with known coronary artery disease.
  • Women with significant cardiovascular pathologies and associated medication.
  • Women with type 1 or insulin treated diabetes.
  • Women with diabetes with complications.
  • Women with unstable diabetes or hypertension.
  • Women with any cancer.
  • Women with musculoskeletal impairments or contraindications to exercise.

结局指标

主要结局

Maximal oxygen uptake

时间窗: 6 months

次要结局

  • lipoprotein profile(6 months)
  • Flow mediated dilation(6 months)
  • Cardiac power output(6 months)
  • Arterial stiffness(6 months)
  • Inflammatory markers(6 months)
  • Body composition(6 months)

研究者

申办方类型
Other

研究点 (2)

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