NCT05837065招募中不适用
Development and Validation of Novel Models Including Tumor Micronecrosis for Predicting the Postoperative Survival of Patients With Hepatocellular Carcinoma
Zhejiang University1 个研究点 分布在 1 个国家目标入组 765 人开始时间: 2022年9月15日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 765
- 试验地点
- 1
- 主要终点
- the Harrell concordance index (C-index)
研究概览
简要总结
The heterogeneity of hepatocellular carcinoma (HCC) leads to the unsatisfying predicting performance of current staging systems. HCC patients with pathological tumor micronecrosis have immunosuppressive microenvironment. We aimed to develop novel prognostic models by integrating micronecrosis to more precisely predict the survival of HCC patients after hepatectomy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •pathologically diagnosed as HCC;
- •curative hepatectomy with R0 resection;
- •conserved liver function with Child Pugh class A or B
排除标准
- •with macrovascular invasion or extrahepatic metastasis;
- •receiving other anti-tumor treatments such as TACE or systemic drugs;
- •with other primary cancers;
- •incomplete follow-up data;
- •without sufficient formalin-fixed, paraffin-embedded (FFPE) specimens for micronecrosis evaluation
结局指标
主要结局
the Harrell concordance index (C-index)
时间窗: Up to 5 years
次要结局
- the time-dependent area under the receiver operating characteristic curve(tdAUROC)(Up to 5 years)
研究者
TingBo Liang
Director
Zhejiang University
研究点 (1)
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