ACTRN12623001356651尚未招募2 期
Feasibility of Pregabalin for the treatment of CANVAS associated chronic cough
Richard Roxburgh0 个研究点目标入组 18 人开始时间: 2023年12月21日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 18
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •Participants with neurological symptoms attributable to RFC1 pathology (neuropathy, vestibular failure, ataxia)
- •Positive RFC1 genetic test (either biallelic pathological expansion or pathological expansion and pathological variant).
- •> 1 year of chronic cough
- •18 years and over
- •Can give informed consent.
- •Has access to a smart phone.
排除标准
- •History of cancer (other than skin squamous cell carcinoma (SSC) or basal cell carcinoma (BCC)).
- •History of severe renal impairment (glomerular filtration rate (GFR) < 30)
- •History of intolerance to pregabalin
- •Pregnancy*/breastfeeding.
- •Active respiratory disease.
- •Current or recently quit (< 6 months) smokers.
- •Angiotensin Converting Enzyme (ACE) inhibitor use.
- •Productive cough.
- •Use of any pregabalin, gabapentin within 3 months of baseline visit
- •Comorbid medical condition which, in the opinion of the Principal Investigator (PI) will either confound the outcome of the study, or place the participant at risk
- •Blood test abnormalities at screening indicating severe liver or kidney dysfunction
研究者
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