NCT01246596已完成不适用
Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 2
- 主要终点
- Percentage of gingival epithelial cells infected by EBV (by immunofluorescence and In situ Hybridization)
研究概览
简要总结
The etiopathogenesis of periodontal disease results from complex interaction between infectious agents, mainly including bacteria, and host cellular and humoral immune responses. However it is thought that bacteria-induced pathogenesis is not sufficient alone to explain all biological and clinical features of the destructive periodontal disease. The main hypothesis is that herpesviruses, such as Epstein-Barr Virus, may participate as well by altering epithelial gingival cell biology and consequently may promote the initiation and progression of periodontitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •10 patients affected by chronic periodontitis
- •10 patients affected by aggressive periodontitis
- •10 healthy patients (orthodontics extraction)
- •Subject who have read and understood the information note relative under investigation and who have signed the informed consent
- •major patient
排除标准
- •Patient with no contre-indication to periodontal treatment
- •Patient with serious blood disease
- •Patient who exhibits systemic condition incompatible with realization of the study
- •Patient treated with oral retinoids, bisphosphonates, oral anticoagulants and anticonvulsivants
- •Patient who presents a buccal carcinoma treated with radiotherapy
- •Patient who have received during the past 6 months: anti-inflammatory drugs, anti-cancerous or immunosuppressive chemiotherapy
- •Patient who presents a linguistic or psychic incapacity to understand information
结局指标
主要结局
Percentage of gingival epithelial cells infected by EBV (by immunofluorescence and In situ Hybridization)
时间窗: at time=0
次要结局
- Epithelial tissue infected by EBV (by immunofluorescence and in situ hybridization)(at time = 0)
- Presence / absence of latency and / or lytic proteins (by immunofluorescence and in situ hybridization)(at time = 0)
研究者
研究点 (2)
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