NCT01939678终止不适用
Characterization and Role of Mutations in Sodium-phosphate Cotransporters in Patients With Calcific Aortic Valve Disease
Region Örebro County1 个研究点 分布在 1 个国家目标入组 3 人开始时间: 2013年9月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 3
- 试验地点
- 1
- 主要终点
- Mutations in sodium-phosphate cotransporters in patients with calcific aortic valve disease
研究概览
简要总结
The purpose of this study is to investigate whether mutations in genes coding for Na/Pi-cotransporters are associated with aortic valve calcification. A patient population with premature aortic valve calcification treated with aortic valve replacement will be screened for mutations in these specific genes. Furthermore, aortic valve tissue received from the operations, will be examined for the presence of Na/Pi-cotransporters, and for molecular characterization of the transporters.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with aortic valve calcification that will be treated with an aortic valve replacement.
- •Age ≤ 65 years.
- •Signed and dated informed consent.
排除标准
- •Inability to provide informed consent
- •Earlier radiation therapy of the thorax
- •Severe renal disease (patients in treatment with dialysis)
结局指标
主要结局
Mutations in sodium-phosphate cotransporters in patients with calcific aortic valve disease
时间窗: At the time of aortic valve replacement
Mutations in genes coding for Na/Pi-cotransporters
次要结局
未报告次要终点
研究者
Ole Frobert, MD, PhD
MD, PhD
Region Örebro County
研究点 (1)
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