Toward the Implementation of Genomics in Substance Use Disorder Treatment
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 148
- 试验地点
- 2
- 主要终点
- Change in Use of Smoking Cessation Pharmacotherapy in Past 30 Days
研究概览
简要总结
Cigarette smoking remains one of the leading causes of preventable death. Effective smoking cessation medications exist but use of these treatments is low, making it difficult for most to quit smoking. Behavioral interventions are needed to engage current smokers in the process of quitting smoking and promote the use of evidence-based cessation medications.
At the same time, genetics influences one's smoking behaviors (e.g., how much they smoke, difficulty quitting) and risk of smoking-related diseases, yet these personalized factors have not been included in existing behavioral interventions. Incorporating these individualized factors into smoking cessation interventions may make them more personally engaging and thus motivating for treatment.
This study will pilot test a risk communication tool that is personalized to one's genetics and will demonstrate the feasibility of a larger trial to test the effect of this personalized genetically-informed intervention on smoking cessation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •At least 18 years of age
- •Smoked combustible cigarettes in past 30 days
- •Computer access for remote-based study visits
排除标准
- •Younger than 18 years of age
- •No computer access
结局指标
主要结局
Change in Use of Smoking Cessation Pharmacotherapy in Past 30 Days
时间窗: Baseline, immediately prior to intervention receipt, 30-day follow-up, and 6-month follow-up
Participants in both groups were asked about their use of several smoking cessation medications (Question: "In the past 30 days, have you used any of the following prescription medications or over-the-counter aids to help you quit or cut back on smoking?"; Response options: 1=Bupropion or Zyban; 2=Varenicline or Chantix; 3=Nicotine patch; 4=Nicotine gum or lozenge; 5=Other (Specify).
Change in Number of Cigarettes Smoked Per Day
时间窗: Baseline, immediately prior to intervention receipt, 30-day follow-up, and 6-month follow-up
Participants in both groups were asked "In the past 30 days, how many days did you smoke cigarettes" and "On the days in which you smoked cigarettes in the past month, about how many cigarettes did you smoke". The values from these questions are multiplied together and then divided by 30 (days) to calculate the number of cigarettes smoked per day for each participant.
次要结局
- Change in Perceived Benefits of Cessation(Baseline, immediately following intervention receipt, 30-day follow-up, and 6-month follow-up)
- Change in Perceived Value of Cessation Treatments(Baseline, immediately following intervention receipt, 30-day follow-up, and 6-month follow-up)
- Change in Readiness to Quit Smoking(Baseline, immediately prior to intervention receipt, 30-day follow-up, and 6-month follow-up)
- Change in Perceived Disease Risk(Baseline, immediately following intervention receipt, 30-day follow-up, and 6-month follow-up)
- Personal Relevance of Intervention(Immediately following intervention receipt)
- Change in Self-efficacy of Cessation(Baseline, immediately following intervention receipt, 30-day follow-up, and 6-month follow-up)