Evaluating Skin Barrier Biophysical Properties and Clinical Appearance After Moisturizer Use in Patients With Dry Skin
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 37
- 试验地点
- 2
- 主要终点
- The appearance of xerosis
研究概览
简要总结
The purpose of the study is to compare the changes in the appearance of dry skin after the use various moisturizers: white petrolatum ointment, coconut oil, jojoba oil, and almond oil in patients with dry skin.
详细描述
The goal of this study is to compare how the appearance of dry skin changes before and after the use of following moisturizers: white petrolatum, coconut oil, jojoba oil and almond oil). Up to 40 subjects from Banner-University Medical Center/University of Arizona dermatology clinics and University of California, Davis dermatology clinics (up to 20 subjects per site) who have dry skin will be enrolled in this study and randomized to receive the four moisturizers on four locations on their forearms.There will be a total of 3 study sessions: baseline, and approximately 1 and 2 weeks for follow up assessment. At each visit, dry skin severity will be evaluated by a trained observer using a validated Dry Skin Score, skin barrier biophysical properties (transepidermal water loss and hydration) will be measured, and digital photos of the test sites will be taken for image analysis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male and female, at least 18 years of age
- •Subject must receive a diagnosis of dry skin by a dermatologist.
- •Subject must be able to comprehend and read the English language.
排除标准
- •Subjects who do not fit the inclusion criteria.
- •Subjects unable to or unwilling to comply with the study procedures
- •Prior known allergy to white petrolatum, coconut oil, almond oil, or jojoba oil.
- •People who have used products containing white petrolatum, jojoba oil, coconut oil, or almond oil within the past week.
- •People with a known diagnosis of ichthyosis.
- •A subject who, in the opinion of the investigator, will be un-cooperative or unable to comply with study procedures.
- •Subject unable to speak or read the English language, since all consents and instructions will be provided in English.
- •Those that are prisoners or cognitively impaired
研究组 & 干预措施
white petrolatum ointment
All subjects will apply white petrolatum ointment to a previously randomize section of the skin on the left or right forearm.
干预措施: white petrolatum ointment (Other)
virgin jojoba oil
All subjects will apply virgin jojoba oil to a previously randomize section of the skin on the left or right forearm
干预措施: virgin jojoba oil (Other)
virgin almond oil
All subjects will apply virgin almond oil to a previously randomize section of the skin on the left or right forearm
干预措施: virgin almond oil (Other)
virgin coconut oil
All subjects will apply virgin coconut oil to a previously randomize section of the skin on the left or right forearm.
干预措施: virgin coconut oil (Other)
结局指标
主要结局
The appearance of xerosis
时间窗: 14 days
The clinical severity of xerosis of the 4 location will be graded by a trained observed using a previously validated Dry Skin Scale and by analysis of the digital photos.
次要结局
未报告次要终点