Single Nucleotide Polymorphisms (SNPs) Associated With Postoperative Analgesic Failure After Single-port Video-Assisted Thoracoscopic Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 198
- 试验地点
- 1
- 主要终点
- Postoperative analgesic failure
研究概览
简要总结
Postoperative pain remains relatively high within 48h for Chinese patients who receive video-assisted thoracoscopic surgery. Different patients experience different pain intensity. This suggests that there may be genetic variants that make some patients susceptible to analgesic failure. Using blood samples from patients, the investigators are going to analyze the relationship between single nucleotide polymorphisms (SNPs) in genes that are known to be involved in analgesic failure.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≤ 70 and Age ≥18
- •Selective operation lung section with video-assisted thoracic surgery (VATS)
- •III ≥ American Society of Anesthesiologists classification (ASA classification) ≥I
- •Patients informed and agreed to join the study
排除标准
- •Abnormal function of liver and kidney
- •Allergic- dependence history of alcohol, opioids and Local anesthetics
- •No noncompliance
- •Mental disease history，language communication disorder，cicatricial diathesis
- •Underweight or overweight（BMI<18 or >30)
- •Patients not suitable for clinical subjects for other reasons
- •Sedatives, analgesics, antiemetic drugs and anti pruritus drugs were used within 24hours before the operation.
- •History of previous abnormal anaesthesia
- •Women during pregnancy or lactation
结局指标
主要结局
Postoperative analgesic failure
时间窗: 8 a.m. at the first day after surgery.
Once patient experience at least one of the following situations: 1. Bad patients sleep quality 2. Require extra analgesic drug 3. Low satisfaction with pain control 4. Bolus times \> 1 per hour
次要结局
未报告次要终点