NCT01696708已完成不适用
Study of the Brain Energy Profile Evolution, Using 31Phosphorus-Nuclear Magnetic Resonance Spectroscopy, at Different Stages of Huntington Disease
Institut National de la Santé Et de la Recherche Médicale, France1 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2012年12月6日最近更新:
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Ratio of Inorganic Phosphate (Pi) over phosphocreatine (PCr): Pi/PCr
研究概览
简要总结
The purpose of this project is to study brain energy profile evolution at different stages of the Huntington disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •UHDRS < 50
- •Age > 18 years
- •Ability to undergo MR scanning
- •Covered by french social security
排除标准
- •Evidence of psychiatric disorder
- •Attendant neurological disorder
- •Contraindications to MRI (claustrophobia, metallic or material implants)
- •Severe head injury
- •Unable to understand the protocol
- •Pregnancy
- •Failure to give informed consent
- •Subjects with exclusion criteria required by french law (e.g. subjects who require a legally authorized representative to obtain consent)
- •Unwillingness to be informed in case of abnormal MRI
研究组 & 干预措施
Patients
Other
31-Phosphorus RMN Spectroscopy
干预措施: 31-Phosphorus RMN Spectroscopy (Other)
Volunteers
Other
31-Phosphorus RMN Spectroscopy
干预措施: 31-Phosphorus RMN Spectroscopy (Other)
结局指标
主要结局
Ratio of Inorganic Phosphate (Pi) over phosphocreatine (PCr): Pi/PCr
时间窗: 2 years
31P-MRS allows quantification of high-energy phosphate metabolites such as phosphocreatine and inorganic phosphate
次要结局
- Correlation between primary outcome measure and clinical parameters(2 years)
- Study of longitudinal changes in Pi/PCr ratio over time.(2 years)
研究者
研究点 (1)
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