Effects of Remote Ischemic Preconditioning With Postconditioning in Patients Undergoing Superficial Temporal Artery-middle Cerebral Artery (STA-MCA) Anastomosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 108
- 试验地点
- 2
- 主要终点
- Number of major adverse event
研究概览
简要总结
In the present study, we evaluated whether RIPC with RIPostC reduce the major neurocomplication in patients undergoing STA-MCA anastomosis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists
- •Adults 18 to 65 years of age
- •In patients with planned MCA-STA anastomosis under general anesthesia
- •Patients who pre-agreed to the study
排除标准
- •If there is a history of peripheral vascular arterial or venous disease
- •If there is a previous history of peripheral nerve disease
- •Other brain or cerebrovascular disease
- •In case of serious cardiovascular disease, pulmonary disease, kidney disease
- •Patients who do not agree with the test
研究组 & 干预措施
The control group
The control group has a sphygmomanometer wound around the upper arm or lower extremity and applies the same pressure, but a 3-way stopcock is installed in the middle so that no pressure is applied.
RIPC with RIPostC group
The sphygmomanometer is closed to the lower limb and the cuff is inflated and the pressure is increased by 30 mmHg higher than the systolic blood pressure of each patient for 5 minutes. The loss of the distal pulse is confirmed by Doppler in the dorsalis pedis pulse. If there is a pulse, increase the pressure until it disappears. After 5 minutes of ischemia time, the cuff is deflated to confirm that the pulse has returned and has a reperfusion time of 5 minutes. A total of 4 cycles of 5 cycles of ischemic time and 5 minutes of reperfusion time are performed. (Estimated total 40 minutes) When the skull is started to close, RIpc with RIPostC group performs RpostC and the method is the same as the above RIPC method. (Estimated total 40 minutes)
干预措施: RIPC with RIPostC (Procedure)
结局指标
主要结局
Number of major adverse event
时间窗: postoperative one month
hyperperfusion syndrome, hypoperfusion, EDH, SAH, acute infarction
次要结局
未报告次要终点