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临床试验/NCT07150390
NCT07150390已完成不适用

Aetiologies and Prognosis of Small Bowel Obstruction in Virgin Abdomen

The First Affiliated Hospital with Nanjing Medical University1 个研究点 分布在 1 个国家目标入组 312 人开始时间: 2022年1月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
312
试验地点
1
主要终点
The recurrence rate within 5 years after discharge

研究概览

简要总结

Small bowel obstruction (SBO) is a surgical emergency in which the passage of intestinal contents is prevented due to mechanical obstruction of small intestine. It accounts for almost 50% of all emergency laparotomies with significant in-hospital morbidity and costs. SBO has known to occur in patients who had no prior abdominal surgery, referring to as a virgin abdomen (VA). Nowadays, non-operative management comprising of bowel decompression, water-soluble contrast agents, and fluid resuscitation have been found safe and efficacious in 70% of SBOs caused by adhesions (ASBO). However, based on the assumption that SBO in the virgin abdomen (SBO-VA) is usually caused by other aetiologies than adhesions, such as malignancy and hernias, many authors suggest that surgical exploration is still mandatory. Besides, recent studies do show high incidence of adhesions also in patients with SBO-VA. This observation signifies that guideline on the management of ASBO might also apply to the majority of patients with SBO-VA. Hence, the aim of our retrospectively study is to shed light on the aetiologies of SBO-VA. We believe treatment strategy needs to be based on the underlying reasons of obstructions and conditions of the patients and evaluate their prognosis accordingly.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
14 Years 至 —(Child, Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •Only patients without prior abdominal operations and with CT or surgical exploration confirmation of the diagnosis of SBO were included.

排除标准

  • •Patients with age less than 14 years were excluded in this study.

结局指标

主要结局

The recurrence rate within 5 years after discharge

时间窗: 5 years

The recurrence rate of small bowel obstruction within 5 years after discharge

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Xiaochun Ping

Associate Chief Physician

The First Affiliated Hospital with Nanjing Medical University

研究点 (1)

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