Idiopathic Pulmonary Fibrosis Job Exposures Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 960
- 试验地点
- 1
- 主要终点
- Association between asbestos exposure and IPF
研究概览
简要总结
A case-control study to investigate whether job exposures are an under-recognized cause of idiopathic pulmonary fibrosis (IPF) using an interview to collect information about previous jobs and a blood test to investigate genetic susceptibility.
详细描述
Idiopathic pulmonary fibrosis (IPF) is a scarring lung disease. It damages the air sacs that allow oxygen to be transferred into the blood and transported to vital organs. These changes make people with IPF cough and feel short of breath. It not known what causes the damage. People who get IPF are usually older than 40; it's a very serious illness that cannot be cured and gets worse over time. Statistics show that IPF is becoming more common in the UK but it's not known why. It can be difficult for doctors to tell if someone has IPF or another disease called asbestosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •New diagnosis of IPF between February 2017 and October 2019
排除标准
- •Unable to give informed consent
- •Ever worked outside of the UK
- •For controls
- •Inclusion Criteria:
- •New outpatient department attendee between February 2017 and October 2019
- •Exclusion Criteria:
- •Unable to give informed consent
- •Ever worked outside of the UK (does not include work outside the UK by members of the armed forces or merchant navy)
- •Diagnosis of IPF
结局指标
主要结局
Association between asbestos exposure and IPF
时间窗: 2 years
estimated using logistic regression for any vs no asbestos exposure and adjusting for age and smoking status
次要结局
- Dose-response relationship between asbestos exposure and IPF(2 years)
- Gene-environment interaction (for MUC5B rs35705950 and asbestos exposure) odds ratio.(2 years)