NCT02116829已完成不适用
Is There Room for Butter in a Healthy Diet? - A Randomized Controlled Dietary Human Intervention
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- LDL cholesterol
研究概览
简要总结
The aim of this study is to examine the effects in humans of a moderate butter intake on risk markers of cardiovascular disease compared to a diet with the same amount of olive oil (refined and therefore without polyfenols).
The primary parameters are total cholesterol, LDL- and HDL cholesterol and triglycerides. The secondary parameters are risk markers of diabetes type 2; plasma glucose and insuling as well as the inflammatory marker hs-CRP.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Sign written consent
- •Age: 20-70 y
- •BMI: 18.5 - 32 kg/m2
- •Healthy men and women (with no known diseases)
- •Exclusion criteria
- •Current or previously cardiovascular disease, high blood pressure
- •Diabetes Mellitus or other severe chronic disease, including severe allergies
- •Use of dietary supplements and blood donations prior to, and during the study
- •Known or suspected abuse of alcohol, drugs or medication
- •Pregnant or are planning pregnancy during the study period
- •Extreme physical activity level (more than 10 hours tough physical activity pr. week)
- •Participation in other research studies
- •Inability, physically or mentally, to comply with the procedures required by the study protocol, as evaluated by the study staff
排除标准
- 未提供
结局指标
主要结局
LDL cholesterol
时间窗: 5 weeks
HDL cholesterol
时间窗: 5 weeks
Triglycerides
时间窗: 5 weeks
Total cholesterol
时间窗: 5 weeks
次要结局
- hs-CRP(5 weeks)
- Insulin(5 weeks)
- Glucose(5 weeks)
研究者
Arne Astrup
Professor
University of Copenhagen
研究点 (2)
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