Tracing Of Real-time glu13Cose Metabolism in Human Immune Cells - Intensive Care Unit
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- 13C6-Glucose Uptake and Metabolism in Immune Cells
研究概览
简要总结
The purpose of this study is to understand how cells of the immune system use the common sugar glucose during critical illness. Investigators will intravenously infuse a non-radioactive carbon-13 glucose tracer into adult intensive care unit (ICU) participants over a few hours and collect immune cells from the blood to track uptake and usage of this glucose within these immune cells.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged 18 or older
- •Admitted to one of the following VUMC adult ICUs: Medical ICU, Pulmonary ICU
- •The participant or legally authorized representative must agree to the genetic analyses required as part of this study
排除标准
- •Prisoner or in police custody
- •Patient desires comfort measures only or has a goals-of-care plan inconsistent with participation in non-beneficial research procedures
- •Hemoglobin less than 8 g/dL
- •Uncontrolled hyperglycemia (persistent blood glucose >300 mg/dL) or any clinical condition in which additional IV glucose administration is not appropriate in the opinion of the Study Coordinator, PI, or treating ICU team
- •Current participation in another study where the total volume of blood drawn, when added to this study blood draw volume, exceeds 500 mL in an 8-week period
- •Unable to safely obtain vascular access required for study infusion and blood collection
- •Clinical instability or anticipated clinical care needs that would make the study procedure inappropriate at that time in the opinion of the Study Coordinator, PI, or treating ICU team
- •Any medical issue or pharmacologic exposure which, in the opinion of the study investigator, might interfere with the study objectives
- •Any reason which, in the opinion of the study investigator, adds additional risk to the patient
研究组 & 干预措施
13C6-Glucose
Participants will receive 10-25 grams of 13C6-glucose intravenously over 2-4 hours during a single ICU study procedure.
干预措施: 13C6-Glucose (Drug)
结局指标
主要结局
13C6-Glucose Uptake and Metabolism in Immune Cells
时间窗: Up to 4 hours
Following 13C6-glucose infusion, peripheral blood immune cell populations will be magnetically isolated from collected blood and analyzed by mass spectrometry to quantify 13C6-glucose and downstream 13C-labeled metabolites.
次要结局
未报告次要终点
研究者
Matthew Stier
Assistant Professor of Medicine
Vanderbilt University Medical Center