Does allopurinol (a xanthine oxidase inhibitor) have clinically useful anti-ischaemic effects in angina pectoris? - A randomised, double-blind, placebo-controlled trial

niversity of Dundee0 个研究点开始时间: 2006年11月22日最近更新: 2017年7月3日

适应症

试验速览

暂无简介。

•Patients who fulfill all of the followings:
•1) age between 30 and 85 years
•2) documented coronary artery disease on coronary angiography
•3) angina pectoris for > 2 months
•4) stable anti-anginal therapy for > 1 month
•5) 2 positive exercise treadmill tests for ischaemia, done within a 2 week period and the time to ST depression on the second exercise test must be within 15% of the first test
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•Patients will be excluded if they:
•1) do not fulfill any of the inclusion criteria
•2) have heart failure or left ventricular systolic dysfunction (LV ejection fraction < 45% or LV fraction shortening < 25%)
•3) had a myocardial infarction or acute coronary syndrom within the last 2 months
•4) have ST abnormalities making it difficult to interprete their ECGs (including patients on digoxin)
•5) have significant renal impairment (creatinine > 180)
•6) have gout and already on allopurinol

发起方

niversity of Dundee