NCT03014284撤回不适用
Novel Listeria Vectors Secreting Gut Flora-Altering Agents to Prevent Colon Cancer and Treat Colitis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Expression of B7-H1
研究概览
简要总结
This is a simple tissue collection study with no therapeutic intent. Colon tissues will be taken from standard of care procedures. Tissues will be tested for their functions, expression of immune co-signaling molecules and reactions to transduction with recombinant Listeria vectors to assess effects on expression of B7-H1 and cytokines.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Able to provide informed consent (or have consent provided through a guardian)
- •No immune-modulating drug use during study or within 30 days prior to enrollment
- •Having colon material collected as part of standard of care
排除标准
- •Unable to provide informed consent (or have consent provided through a guardian)
- •Not having colon material collected as part of standard of care
结局指标
主要结局
Expression of B7-H1
时间窗: Baseline tissue collection
To assess the ability of recombinant Listeria to modulate B7-H1 in human colonic tissues
次要结局
未报告次要终点
研究者
研究点 (1)
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