Determination of the Difference in Uptake and Utilization of Two Amino Acids by the Splanchnic Bed
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 6
- 试验地点
- 1
- 主要终点
- Breath VCO2
研究概览
简要总结
Splanchnic uptake and metabolism contributes significantly to the differences in flux seen between the intravenous and intragastric ingestion of certain indispensable amino acids.
This is the third in a series of studies designed to increase the investigators knowledge of the metabolism of two indispensable amino acids, threonine and lysine, by the splanchnic bed. In the initial two studies the investigators established the neonatal parenteral requirement of threonine and lysine. In the current study, the investigators will be examining the differences in uptake and metabolism of threonine and lysine across the splanchnic bed.
详细描述
We propose that we will see a smaller amount of enterally fed isotopes reach the plasma as compared to the amount in plasma from the parenterally delivered isotopes. We also believe that the amount of enterally delivered threonine isotope that reaches the plasma will be significantly less than the amount of enterally fed lysine isotope.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy Males
排除标准
- •History of inborn error of metabolism
- •Presence of a chronic disease
- •Have unusual dietary practices
- •Has recently lost weight
- •Receiving pharmacological therapy or hormonal treatment
研究组 & 干预措施
Study Period 1
AA given by parenteral and enteral routes with tracer 1-13C phenylalanine given to observe differences
干预措施: Threonine Experimental: Study Period 1 (Other)
Study Period 2
AA given by parenteral and enteral routes with tracer 1-13C phenylalanine given to observe differences
干预措施: Lysine Experimental: Study Period 2 (Other)
结局指标
主要结局
Breath VCO2
时间窗: -30min, -20min, -10min, +2.5hrs, +3 hrs, +3.5hrs, +4hrs,+4.5hrs, +5hrs
Blood CO2
时间窗: -30min, -20min, -10min, +2.5hrs, +3 hrs, +3.5hrs, +4hrs,+4.5hrs, +5hrs
次要结局
未报告次要终点
研究者
Karen Chapman
Clinical Research Nurse Specialist
The Hospital for Sick Children