Comparison of the Effect of Various External Pressure on Blood During Rapid Infusion
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Hemolysis and alteration of deformability of red blood cell caused by external pressure
研究概览
简要总结
Rapid infusion of blood is needed occasionally for control massive bleeding. For rapid infusion, external pressure can be used. The investigators will study correlation between external pressure and hemolysis and deformability of red blood cell.
详细描述
Rapid infusion of blood is needed occasionally for control massive bleeding. For rapid infusion, external pressure can be used which cause hemolysis and alteration of red blood cell. The investigators will study correlation between variable external pressure and hemolysis and deformability of red blood cell. Differ from previous study, the investigator will use scanning electron microscope for observation red blood cell.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy volunteers, without any underlying disease.
排除标准
- •history of delivery, abortion in past 6 months.
- •weight : male under 50kg, female under 45kg
- •heart rate under 50 or over 100
- •fever : over 37.5
- •blood pressure : over 180/100
研究组 & 干预措施
5days
5 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.
干预措施: Auto PC(Acemedical, Goyang-si, Korea) - 0mmHg(control) (Device)
5days
5 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.
干预措施: Auto PC(Acemedical, Goyang-si, Korea) - 150mmHg (Device)
5days
5 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.
干预措施: Auto PC(Acemedical, Goyang-si, Korea) - 200mmHg (Device)
5days
5 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.
干预措施: Auto PC(Acemedical, Goyang-si, Korea) - 250mmHg (Device)
5days
5 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.
干预措施: Auto PC(Acemedical, Goyang-si, Korea) - 300mmHg (Device)
35days
35 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.
干预措施: Auto PC(Acemedical, Goyang-si, Korea) - 0mmHg(control) (Device)
35days
35 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.
干预措施: Auto PC(Acemedical, Goyang-si, Korea) - 150mmHg (Device)
35days
35 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.
干预措施: Auto PC(Acemedical, Goyang-si, Korea) - 200mmHg (Device)
35days
35 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.
干预措施: Auto PC(Acemedical, Goyang-si, Korea) - 250mmHg (Device)
35days
35 days after blood sampling, various external pressure test will be done. Blood wil be stored in refrigerator(Celsius 4 degree) until study day. External pressure 0, 100, 150, 200, 250, 300mmHg will be applied to each blood sample.
干预措施: Auto PC(Acemedical, Goyang-si, Korea) - 300mmHg (Device)
结局指标
主要结局
Hemolysis and alteration of deformability of red blood cell caused by external pressure
时间窗: 1hour
次要结局
未报告次要终点
研究者
Hyub Huh
M.D.
Korea University Anam Hospital