跳至主要内容
临床试验/NCT00219518
NCT00219518终止不适用

Mechano-physiological Approach to Normal Anorectal Function and the Classification of Defecatory Disorders

Milton S. Hershey Medical Center1 个研究点 分布在 1 个国家目标入组 17 人开始时间: 2006年2月最近更新:
适应症

试验速览

阶段
不适用
状态
终止
入组人数
17
试验地点
1
主要终点
change in shape of anorectum during changes in intraabdominal pressure and defecation

研究概览

简要总结

We hypothesize that defecatory disorders can be described in mechanical terms which would allow a mechanistic description of disorders which would in turn allow better directed biofeedback mechanisms to treat disorders of defecation.

详细描述

Disorders of defecation are very common and the process of defecation remains poorly described. This results in a limited approach to treatment of patients, with limited success. This study will simultaneously measure multiple components of the process of defecation - the abdominal wall and perineal muscle activity, the pressure within the rectum and in the anal canal and the change in shape of the anorectal region of the colon, in order to develop a biomechanical model which can describe the normal and abnormal defecatory process. It is anticipated that, by understanding the process in these terms will allow a new approach to categorizing and describing defecation problems which in turn will lead to more specific approaches of treatment which will be tailored to individual patients. These parameters will compared in volunteers with no defecatory disorders and patients with defecatory disorders who are being referred for defecography as part of their clinical evaluation.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Prospective

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
Female
接受健康志愿者

入选标准

  • No defecatory problems
  • On no medication which affect bowel habits

排除标准

  • Pregnancy
  • Inclusion Criteria:
  • Difficulty in defecation
  • Exclusion criteria:
  • Pregnancy
  • Medication which can affect bowel movement

结局指标

主要结局

change in shape of anorectum during changes in intraabdominal pressure and defecation

时间窗: start of anorectal manometry procedure until procedure end

measure change in dimension over time

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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