ISRCTN23139643进行中（未招募）未知
Restricted versus liberal fluid administration strategy in severe traumatic brain injury (RELIST). A randomized clinical trial
试验速览
- 阶段
- 未知
- 状态
- 进行中（未招募）
- 入组人数
- 600
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Age = 14 years
- •2. Severe TBI (GCS <9)
- •3. Within 24 hours of the incidence of trauma provided that the resuscitation phase is complete (post-resuscitation phase)
- •4. Isolated non-penetrating head injury
- •5. Clinical necessity for ICP management per BTF recommendations
- •6. Mechanically ventilated, without any evidence of respiratory dysfunction (P/F ration = 250).
- •7. Hemodynamically stable or on vasopressor support for standardized CPP management according to BTF recommendations: MAP = 65 mmHg
- •8. SBP = 90 mmHg
排除标准
- •1. Pregnancy
- •2. Neurological examination suggesting eminent brain death
- •3. Multiple trauma
- •4. Severe chronic heart failure (NYHA 4)
- •5. Bleeding disorders and/or ICP monitoring contraindicated for other reasons.
- •6. Impaired renal function (Creatinine > 200 mmol/L)
- •7. Patients without fixed address (impossible to follow-up)
研究者
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