Postoperative Infectious Complications Calculator for Elderly Patients--A Derivation and External Validation of Prediction Models Based on Two Centers Large Sample
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 37,230
- 试验地点
- 1
- 主要终点
- Postoperative Infectious Complications Calculator for Elderly Patients
研究概览
简要总结
The investigators established a first-ever convenient scoring system for clinicians to assess the risk of Postoperative infectious complications (PICs) for elderly patients. Our scoring system can aid in the early detection of potential risks for postoperative infections. Higher-score patients were more likely to experience postoperative infections.
详细描述
Background:
Postoperative infectious complications (PICs) are related to increased morbidity, mortality, and costs, especially in elderly patients. However, published prediction models of PICs are rarely based on elderly patients.
Objective
The study wanted to identify practical and valuable variables that could be used to predict postoperative infections and establish a convenient scoring system for clinicians to assess the risk of such conditions in elderly patients.
Methods： Data from 2 population-based cohorts of elderly patients undergoing non-cardiac and non-neurology surgery were used to derive and validate multivariable logistic regression models. The risk prediction models were derived from 37230 patients hospitalized in the First Medical Center of the Chinese PLA General Hospital (January 2014 - August 2019). The risk prediction models were externally validated with data from a cohort of 10252 patients hospitalized in Henan Provincial People's Hospital (November 2014 to May 2022).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age ≥ 65 years and
- •patients undergoing surgery with anesthesia.
排除标准
- •patients undergoing neurosurgery or cardiac surgery,
- •preoperative infectious diseases, and
- •patients with ≥50% of data missing.
结局指标
主要结局
Postoperative Infectious Complications Calculator for Elderly Patients
时间窗: January 2012 - August 2018
A Derivation and External Validation of Prediction Models based on two centers large sample
次要结局
未报告次要终点
研究者
Weidong Mi
Director, Department of Anesthesiology, The First Medical Center
Chinese PLA General Hospital