PACTR202308810518432招募中4 期
Open-Label, Randomized Controlled Study Comparing The Efficacy And Tolerability Of Artemether-Lumefantrine And Artesunate-Amodiaquine In Hiv Patients With Kidney Disease Treated With Dolutegravir-Based Antiretroviral Therapy
Dr. Abdulwasiu A Busari0 个研究点目标入组 120 人开始时间: 2023年8月18日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 发起方
- 入组人数
- 120
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 19 Year(s) 至 44 Year(s)（—）
- 性别
- All
入选标准
- •1. Age 18 years and older.
- •2. HIV positive
- •3. Fever (axillary temperature = 37.5°C), or history of fever in previous 48 hours;
- •4. Microscopic confirmation of asexual stages of P. falciparum or mixed infection or malaria parasite densities >2,000/?l
- •5. Receiving ART for at least 3 months.
- •6. Having CKD as evident by GFR <60 mL/min/1.73m2 and/or proteinuria
- •7. Willingness to give informed consent.
排除标准
- •1. Pregnancy.
- •2. Severe/complicated malaria.
- •3.Severe anaemia (<8.5 g/dl haemoglobin (Hb));
- •4. Full course of AA or AL treatment or more than two doses of another antimalarial in the past four weeks.
- •5. Known hypersensitivity to artemisinin derivates, amodiaquine, artemether-lumefantrine, or raltegravir.
- •6. Patient on haemodialysis
- •7. Patient with a history of cardiac arrhythmias
- •8. Not willing to give informed consent
研究者
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