NCT00005033已完成2 期
Phase II Study of Recombinant Humanized Monoclonal Antibody Against HER2 for the Treatment of Recurrent Osteosarcoma
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 试验地点
- 7
研究概览
简要总结
RATIONALE: Monoclonal antibodies, such as trastuzumab, can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
PURPOSE: Phase II trial to study the effectiveness of trastuzumab in treating patients who have recurrent osteosarcoma.
详细描述
OBJECTIVES:
- Determine the response rate, freedom from progression, and survival of patients with recurrent osteosarcoma when treated with trastuzumab (Herceptin).
- Evaluate the toxicity of this drug in young patients with a history of osteosarcoma and prior therapy with doxorubicin.
OUTLINE: This is a multicenter study.
Patients receive trastuzumab (Herceptin) IV over 30-90 minutes weekly. Treatment continues for up to 52 weeks in the absence of disease progression or unacceptable toxicity. After approximately 12 weeks of treatment, patients are evaluated for response and undergo surgical resection if clinically appropriate.
Patients are followed for 1 year for survival.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究者
研究点 (7)
Loading locations...
相似试验
已完成
2 期
Trastuzumab Plus Paclitaxel in Treating Women With Metastatic Breast Cancer That Overexpresses HER2Breast CancerNCT00005635Genentech, Inc.
已完成
2 期
Trastuzumab Plus Docetaxel in Treating Women With Recurrent or Metastatic Breast CancerBreast CancerNCT00006104Vanderbilt-Ingram Cancer Center46
已完成
2 期
Trastuzumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial CancerEndometrial AdenocarcinomaERBB2 Gene AmplificationRecurrent Uterine Corpus CarcinomaStage III Uterine Corpus Cancer AJCC v7Stage IV Uterine Corpus Cancer AJCC v7NCT00006089National Cancer Institute (NCI)34
撤回
3 期
Trastuzumab With or Without Tamoxifen in Treating Women With Progressive Stage IV Breast CancerStage IV Breast CancerRecurrent Breast CancerNCT00053339Alliance for Clinical Trials in Oncology
撤回
2 期
Monoclonal Antibody Therapy in Treating Patients With Primary Myelodysplastic SyndromeMyelodysplastic SyndromesNCT00003984European Organisation for Research and Treatment of Cancer - EORTC