Inhibition of Dental Plaque Regrowth by an Ethanol-Free 0,2% Chlorhexidine Mouth Rinsing Solution

GlaxoSmithKline Consumer Healthcare GmbH & Co. KG0 个研究点目标入组 42 人开始时间: 2007年8月15日最近更新: 2012年3月19日

试验速览

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•Inclusion Criteria:
•– healthy volunteers
•– minimum number of 20 natural teeth in the mouth
•– age = 20 = 50 years
•– regular dental care at home
•– healthy mucosa with the exception of gingivitis simplex or periodontal recessions
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•Exclusion Criteria:
•– systemic diseases
•– participation in a clinical trial within the last 30 days or subject has already
•participated in this clinical study
•– regular use of drugs interfering with plaque formation or the generation of gingival
•inflammations (4 weeks before and during recruitment)
•oantibiotics acting locally in the mouth or systemically
•osteroidal and non-steroidal antiphlogistics
•odrugs which influence salivation (e.g. antihistaminics, anticholinergics,
•drugs against hypertension, psychotropics)
•– pregnancy or lactation
•– necessity of antibiotic protection prior to dental treatment interventions
•– current orthodontic therapy or extended restorations
•– known hypersensitivity to ingredients of the study medication
•– all types of known allergies
•– scheduled surgical intervention or hospitalization within the next 6 weeks
•– open wounds and ulcers inside the oral cavity
•– superficial, non-bleeding exfoliation of the oral mucosa or other acute local
•diseases of the oral mucosa (exception: gingivitis simplex)
•– present or previous alcoholism

发起方