Intermittent Preventive Treatment in Infant in Mali
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 试验地点
- 2
- 主要终点
- EPI vaccines and other health interventions coverage
研究概览
简要总结
Studies have shown that Intermittent preventive treatment in infants (IPTi) with Sulfadoxine-pyrimethamine (SP)reduced the incidence of clinical malaria and anemia without modifying infants' serological response to EPI vaccines. Thus IPTi was seen as a potential public health tool of great benefit to the children of Africa and a logical addition to the Immunization Plus package. The objectives of this operational researcher were
- to develop an implementation model for IPTi in the health care system in Mali
- to assess its impact on the EPI vaccines and other health interventions coverage
- and on molecular makers of resistance to SP
详细描述
The study was implemented in districts of the region of Koulikoro; the district of Koulikoro and the district of Kolokani. The whole district of Koulikoro was covered by the intervention while in Kolokani, the 22 health areas (sub districts) were randomized in 1:1 ratio with the intervention in 11 health areas and the other 11 serving as control for the assessment of the impact of IPTi implementation on EPI vaccines and other health interventions coverage as well as its impact on the resistance to SP. The implementation consisted of administration of ½ tablet of Sulfadoxine -Pyrimethamine with EPI vaccines (DTP2, DTP3 and Measles vaccine) from December 2006 to December 2007.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- — 至 23 Months（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Resident of Kolokani, Mali
- •Age less than 24 months
排除标准
- •Not Resident of Kolokani
- •Age of 24 months or above
结局指标
主要结局
EPI vaccines and other health interventions coverage
时间窗: 1 year
Molecular makers of resistance of P. falciparum to Sulfaxodine- pyrimethamine
时间窗: 1 year
次要结局
未报告次要终点