Influence of Preprandial Metformin Administration on Carbohydrate Absorption: Pilot Randomized Controlled Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1
- 主要终点
- Area under the curve of D-Xylose
研究概览
简要总结
Type 2 diabetes is spreading worldwide as well as obesity. Metformin is the most prescribed antidiabetic medication. One suggested mechanism of action is by decreasing carbohydrate absorption.
It is usually recommended to take metformin during the meal to decrease gastrointestinal side effects. However, if metformin decreases carbohydrate absorption, this might not be the most efficient intake.
To study the influence of preprandial metformin administration on carbohydrate absorption, it will repeat 3 oral glucose tolerance test on obese dysglycemic patients, without metformin or with metformin administer 30 or 60 minutes before. We will also evaluate how it impacts gastrointestinal tolerance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Obesity (BMI ≥30 kg/m2)
- •Dysglycemia (HbA1c≥ 6,0 %)
- •No anti diabetic medication
排除标准
- •No obesity (BMI < 30 kg/m2)
- •No dysglycemia (HbA1c <6,0%)
- •Treatment that might interfere with carbohydrate absorption (anti diabetic medication, antibiotics, probiotics, steroids)
- •Anemia (Hb <12 g/dL)
- •Organ failure
- •Inflammatory Bowel Disease
研究组 & 干预措施
taking metformin 30 or 60 minutes before the OGTT
干预措施: Oral glucose tolerance test (OGTT) with or without metformin (Other)
No metformin before OGTT
干预措施: Oral glucose tolerance test (OGTT) with or without metformin (Other)
结局指标
主要结局
Area under the curve of D-Xylose
时间窗: During the 3 hours OGTT
次要结局
- Area under the curve of blood glucose(During the 3 hours OGTT)
- Number of Participants with gastrointestinal side effects(During the 3 hours OGTT)
- Area under the curve of insulin(During the 3 hours OGTT)
- Area under the curve of GLP-1(During the 3 hours OGTT)