Neurobiology of Posttraumatic Stress Disorder Dysfunction and Recovery Following Cognitive Processing Therapy
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 130
- 试验地点
- 2
- 主要终点
- Potential Change in Evidence of PTSD symptoms with neuroimaging
研究概览
简要总结
Posttraumatic stress disorder (PTSD) is a significant personal and societal burden. The purpose of this study is to examine genetic, epigenetic, behavioral, and brain activity changes related to PTSD dysfunction and recovery before and after treatment with Cognitive Processing Therapy.
详细描述
Using functional magnetic resonance imaging approaches, the present research aims to examine the relationship between traumatic experience and the neural mechanisms of various PTSD symptoms, and determine how this relationship changes during PTSD extinction. Also, this proposal aims to better understand how the genetic/epigenetic profile of several genes predicts, and perhaps changes, in response to recovery from PTSD along with its neural correlates. This understanding will help identify individuals who will respond most optimally to a specific empirically based PTSD treatment, Cognitive Processing Therapy, while further connecting genetic biomarkers of risk with neural intermediate phenotypes underlying PTSD symptomatology.This study is observational as the investigator does not assign specific interventions to the participants of the study.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •PTSD diagnosis, as measured by the Clinician Administered PTSD Scale for DSM-5
- •history of chronic childhood trauma due to relational abuse
- •Ability to understand and sign informed consent
- •Enrollment in CPT program at McLean Hospital
- •Both genders, all ethnic backgrounds, age between 18 and 55
- •Fluent English speakers
- •Normal or Corrected Vision
排除标准
- •History or current schizophrenia spectrum disorder or other psychotic disorders
- •History or current bipolar or other related disorders
- •Alcohol and/or substance use disorder within the past month
- •Metal implants
- •Medical or neurological illness (e.g., seizures, head injury in which they experienced a loss of consciousness)
- •Positive pregnancy test
结局指标
主要结局
Potential Change in Evidence of PTSD symptoms with neuroimaging
时间窗: Within 30 days before and again within 30 days after Cognitive Processing Therapy Treatment.
次要结局
未报告次要终点
研究者
Milissa Kaufman
Medical Director, Hill Center for Women
Mclean Hospital