Association of Seminal Plasma SARS-Cov19 IgG Level With Semen Parameters and Embryological Characteristics in Vaccinated Normozoospermic Men
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- semen index
研究概览
简要总结
Since December 2019, more and more cases of unexplained pneumonia appeared after exposure to the South China Seafood Market in Wuhan City, Hubei Province. Later, the disease were confirmed to be acute respiratory infectious diseases caused by the 2019 new coronavirus infection.
Even though we have had great victories in the war against this pandemic, there is still a very large number of deaths early on. As research progresses, vaccines for this infectious disease are already being developed. There are currently two vaccines in widespread use worldwide: mRNA vaccines and inactivated vaccines. In China, inactivated vaccines are more commonly used. At present, some studies believe that mRNA vaccine does not affect the pregnancy rate and abortion rate of women, but the study sample size is small, and the conclusions are limited. The effects of inactivated vaccines on fertility are still in the blank. We now hope to conduct prospective studies, mainly to study the effect of inactivated vaccine injection on male semen, and whether it has an effect on the quality of embryos in IVF patients
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 22 Years 至 50 Years(Adult)
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •The man's semen quality is normal,
- •The couple meets the indications for IVF,
- •injected with the covid-19 vaccine
排除标准
- •In vitro fertilization due to male factors
- •Azoospermia
- •The quality of the man's semen is abnormal
结局指标
主要结局
semen index
时间窗: 2022.01-2022.03
the semen index of the participants
次要结局
- embryo quality(2022.02-2022.05)
- clinical pregnant rate(2022.03-2022.05)
- Fertilization rate(2022.01-2022.04)
研究者
chen zhi qin
doctor
Shanghai First Maternity and Infant Hospital
